Full Product Name
Anti-Human CD41 Monoclonal Antibody (PE/Cy5 Conjugated)
Product Synonym Names
Integrin alpha-Iib; ITGA2B; GPalpha Iib; GPIIb; Platelet membrane glycoprotein Iib; CD41; GP2B; ITGAB
Product Gene Name
anti-CD41 antibody
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Matching Pairs
Antibody: CD41 Clone #HIP8 (MBS2558514)
Isotype Control: IgG1, kappa Clone #MOPC-21 (MBS2557735)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P08514
Form/Format
PBS with 0.05% Proclin300, 1% BSA
Preparation and Storage
Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CD41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD41 antibody
CD41 is a 125/25 kD alpha subunit of the gpIIb/IIIa (CD41/CD61) complex. CD41 is a heterodimer composed of a heavy chain (gpIIbalpha) and light chain (gpIIbbeta) linked by a single disulfide bond. It is a member of the integrin family primarily expressed on platelets and megakaryocytes. CD41 has been reported to be involved with platelet aggregation and platelet attachment to the ECM. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor and thrombin.
Applications Tested/Suitable for anti-CD41 antibody
Flow Cytometry (FC/FACS)
NCBI/Uniprot data below describe general gene information for CD41. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000410.2
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NCBI GenBank Nucleotide #
NP_000410.2
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UniProt Primary Accession #
P08514
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UniProt Related Accession #
P08514[Other Products]
NCBI Official Full Name
integrin alpha-IIb preproprotein
NCBI Official Synonym Full Names
integrin subunit alpha 2b
NCBI Official Symbol
ITGA2B [Similar Products]
NCBI Official Synonym Symbols
GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93
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NCBI Protein Information
integrin alpha-IIb
UniProt Protein Name
Integrin alpha-IIb
UniProt Synonym Protein Names
GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb
UniProt Gene Name
ITGA2B [Similar Products]
UniProt Synonym Gene Names
GP2B; ITGAB; GPIIb [Similar Products]
UniProt Entry Name
ITA2B_HUMAN
NCBI Summary for CD41
This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]
Research Articles on CD41
1. 60 pN that peaked at 70-80 pN.">alphaIIbbeta3 binding to polymeric fibrin can be segregated into two binding regimes, one with weaker rupture forces of 30-60 pN and a second with stronger rupture forces >60 pN that peaked at 70-80 pN.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
