CD41, Monoclonal Antibody

Integrin alpha-Iib; ITGA2B; GPalpha Iib; GPIIb; Platelet membrane glycoprotein Iib; CD41; GP2B; ITGAB

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

HIP8

Mouse

Liquid; PBS with 0.05% Proclin300, 1% BSA

Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-CD41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CD41 is a 125/25 kD alpha subunit of the gpIIb/IIIa (CD41/CD61) complex. CD41 is a heterodimer composed of a heavy chain (gpIIbalpha) and light chain (gpIIbbeta) linked by a single disulfide bond. It is a member of the integrin family primarily expressed on platelets and megakaryocytes. CD41 has been reported to be involved with platelet aggregation and platelet attachment to the ECM. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor and thrombin.

Flow Cytometry (FC/FACS)

Human peripheral blood lymphocytes are stained with Anti-Human CD41 Monoclonal Antibody (Alexa Fluor 488 Conjugated)(filled gray histogram). Unstained lymphocytes (empty black histogram) are used as control.

103,218 Da

integrin subunit alpha 2b

integrin alpha-IIb

Integrin alpha-IIb

GP2B; ITGAB; GPIIb  [Similar Products]

This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

1. Denzin L, et al. 1996. J. Exp. Med. 184:2153. 2. Denzin L, et al. 1995. Cell 82:155. 3. Riberdy J, et al. 1994. J. Cell Biol. 125:1225.

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