Full Product Name
CISD2 Polyclonal Antibody
Product Synonym Names
ERIS; WFS2; ZCD2; NAF-1; Miner1
Product Gene Name
anti-CISD2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purification
Immunogen
Recombinant protein of human CISD2
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CISD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CISD2 antibody
Western Blot (WB)
Application Notes for anti-CISD2 antibody
WB: 1:500 - 1:2000
Western Blot (WB) of anti-CISD2 antibody
Western blot analysis of extracts of various cell lines, using CISD2 antibody.
NCBI/Uniprot data below describe general gene information for CISD2. It may not necessarily be applicable to this product.
NCBI GenBank Nucleotide #
NM_001008388.4
[Other Products]
UniProt Secondary Accession #
Q7Z3D5[Other Products]
UniProt Related Accession #
Q8N5K1[Other Products]
NCBI Official Full Name
CDGSH iron-sulfur domain-containing protein 2
NCBI Official Synonym Full Names
CDGSH iron sulfur domain 2
NCBI Official Symbol
CISD2 [Similar Products]
NCBI Official Synonym Symbols
ERIS; WFS2; ZCD2; NAF-1; Miner1
[Similar Products]
NCBI Protein Information
CDGSH iron-sulfur domain-containing protein 2
UniProt Protein Name
CDGSH iron-sulfur domain-containing protein 2
UniProt Synonym Protein Names
Endoplasmic reticulum intermembrane small protein; MitoNEET-related 1 protein; Miner1; Nutrient-deprivation autophagy factor-1; NAF-1
Protein Family
CDGSH iron-sulfur domain-containing protein
UniProt Gene Name
CISD2 [Similar Products]
UniProt Synonym Gene Names
CDGSH2; ERIS; ZCD2; Miner1; NAF-1 [Similar Products]
UniProt Entry Name
CISD2_HUMAN
NCBI Summary for CISD2
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
UniProt Comments for CISD2
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca2+ stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
Research Articles on CISD2
1. CISD2 protein may serve as a candidate prognostic marker and a novel therapeutic target for hepatocellular carcinoma (HCC) and play an important role in promoting proliferation and enhanced progression of HCC.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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