PPP1R9B, Polyclonal Antibody

Neurabin-2; Neurabin-II; Protein phosphatase 1 regulatory subunit 9B; Spinophilin; PPP1R9B; PPP1R6

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This PPP1R9B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human PPP1R9B.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-PPP1R9B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Spinophilin is a regulatory subunit of protein
phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly
enriched in dendritic spines, specialized protrusions from
dendritic shafts that receive most of the excitatory input in the
central nervous system (Allen et al., 1997 [PubMed
9275233]).

Neuroscience; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

PPP1R9B Antibody (N-term) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the PPP1R9B antibody detected the PPP1R9B protein (arrow).

89192

protein phosphatase 1, regulatory subunit 9B

neurabin-2

Neurabin-2

PPP1R6  [Similar Products]

NEB2_HUMAN

This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]

Spinophilin: actin-binding regulatory subunit of protein phosphatase 1 (PP1). The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines. May play a role in establishing a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Interacts with p14-ARF. Contains one PDZ/DHR domain.

Protein type: Protein phosphatase, regulatory subunit; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: nucleoplasm; cortical actin cytoskeleton; adherens junction; lamellipodium; cytoplasm; dendritic spine; plasma membrane; synapse; protein phosphatase type 1 complex; filopodium

Molecular Function: protein binding; actin binding; protein phosphatase inhibitor activity; protein phosphatase 1 binding

Biological Process: regulation of synaptic transmission; regulation of protein amino acid phosphorylation; regulation of cell growth by extracellular stimulus; cell migration; filopodium formation; RNA splicing; regulation of exit from mitosis; calcium-mediated signaling; actin filament organization; regulation of cell proliferation; negative regulation of catalytic activity; dendrite development; negative regulation of cell growth; cell cycle arrest

Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Rajagopal, S., et al. J. Biol. Chem. 285(23):18060-18071(2010)
Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)
Sagara, M., et al. Oncogene 28(10):1357-1365(2009)
Meng, X., et al. Eur. J. Immunol. 39(2):552-560(2009)

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