Neurabin-2, ELISA Kit

Neurabin-2; Neurabin-II; Protein phosphatase 1 regulatory subunit 9B; Spinophilin; PPP1R9B; PPP1R6

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of PPP1R9B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2887462 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Neurabin-2 (PPP1R9B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PPP1R9B. The ELISA analytical biochemical technique of the MBS2887462 kit is based on PPP1R9B antibody-PPP1R9B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PPP1R9B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PPP1R9B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

89,192 Da

protein phosphatase 1 regulatory subunit 9B

neurabin-2

Neurabin-2

PPP1R6  [Similar Products]

NEB2_HUMAN

This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]

Spinophilin: actin-binding regulatory subunit of protein phosphatase 1 (PP1). The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines. May play a role in establishing a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Interacts with p14-ARF. Contains one PDZ/DHR domain.

Protein type: Adaptor/scaffold; Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: actin cytoskeleton; adherens junction; cytoplasm; dendrite; dendritic spine; filopodium; lamellipodium; nucleoplasm; plasma membrane; postsynaptic density; protein phosphatase type 1 complex

Molecular Function: actin filament binding; protein binding; protein phosphatase 1 binding; protein phosphatase inhibitor activity

Biological Process: actin filament organization; calcium-mediated signaling; cell cycle arrest; cell migration; filopodium formation; negative regulation of catalytic activity; negative regulation of cell growth; neurite development; regulation of cell growth by extracellular stimulus; regulation of cell proliferation; regulation of exit from mitosis; regulation of synaptic transmission; RNA splicing

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