Full Product Name
Hes7 Polyclonal Antibody
Product Gene Name
anti-Hes7 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9BYE0
Species Reactivity
Human (Predicted Reactivity: Mouse
Form/Format
Purified (Liquid)
Concentration
0.5mg/ml, 200µl (lot specific)
Immunogen
A full length recombinant Hes7 protein was used as the immunogen for this antibody.
Preparation and Storage
Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.
Other Notes
Small volumes of anti-Hes7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-Hes7 antibody
Cell Signalling
Applications Tested/Suitable for anti-Hes7 antibody
Western Blot (WB)
Application Notes for anti-Hes7 antibody
Western Blot: 0.5-1 µg/ml
Western Blot (WB) of anti-Hes7 antibody
Expression analysis of Hes7. Anti-Hes7 antibody (11-8084) was used at 1 µg/ml on 293 lysate.
NCBI/Uniprot data below describe general gene information for Hes7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001159439.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001165967.1
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UniProt Primary Accession #
Q9BYE0
[Other Products]
UniProt Secondary Accession #
F8VPC9[Other Products]
UniProt Related Accession #
Q9BYE0[Other Products]
Molecular Weight
25,280 Da
NCBI Official Full Name
transcription factor HES-7 isoform 1
NCBI Official Synonym Full Names
hes family bHLH transcription factor 7
NCBI Official Symbol
HES7 [Similar Products]
NCBI Official Synonym Symbols
SCDO4; bHLHb37
[Similar Products]
NCBI Protein Information
transcription factor HES-7; bHLH factor Hes7; class B basic helix-loop-helix protein 37; hHes7; hairy and enhancer of split 7
UniProt Protein Name
Transcription factor HES-7
UniProt Synonym Protein Names
Class B basic helix-loop-helix protein 37; bHLHb37; Hairy and enhancer of split 7; bHLH factor Hes7
Protein Family
Transcription factor
UniProt Gene Name
HES7 [Similar Products]
UniProt Synonym Gene Names
BHLHB37; hHes7; bHLHb37 [Similar Products]
UniProt Entry Name
HES7_HUMAN
NCBI Summary for Hes7
This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Comments for Hes7
HES7: Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation. Defects in HES7 are the cause of spondylocostal dysostosis type 4 (SCDO4). A rare condition of variable severity characterized by vertebral and costal anomalies. The main feature include dwarfism, vertebral fusion, hemivertebrae, posterior rib fusion, reduced rib number, and other rib malformations.
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: nucleus
Molecular Function: protein dimerization activity; DNA binding; transcription factor binding
Biological Process: somitogenesis; Notch signaling pathway; transcription, DNA-dependent; rhythmic process; mesoderm development; negative regulation of transcription from RNA polymerase II promoter; regulation of somitogenesis; skeletal development
Disease: Spondylocostal Dysostosis 4, Autosomal Recessive
Research Articles on Hes7
1. mutation of HES7 is uniquely associated with defects in vertebral, heart and neural tube formation, and this observation will help provide a discriminatory diagnostic guide in patients with SCD, as well as inform molecular genetic testing.
Precautions
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Disclaimer
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