Hairy and Enhancer of Split 7, Recombinant Protein

HES7 Human; Hairy and Enhancer of Split 7 Human Recombinant; Hairy and enhancer of split 7; bHLHb37; SCDO4; Transcription factor HES-7; HES7; hHes7; Class B basic helix-loop-helix protein 37; bHLH factor Hes7

For Research Use Only. Not for use in diagnostic procedures.

E Coli

Greater than 85% as determined by SDS-PAGE.

The HES7 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Sterile Filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Small volumes of HES7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Description: HES7 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 253 amino acids (1-230) and having a molecular mass of 27kDa. HES7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: HES7 belongs to the Hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of the HES7 is set by Notch signaling. The protein serves as a transcriptional repressor, and is involved in correct patterning of the axial skeleton. A mutation in HES7 has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been discovered for HES7.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

25,280 Da

hes family bHLH transcription factor 7

transcription factor HES-7; bHLH factor Hes7; class B basic helix-loop-helix protein 37; hHes7; hairy and enhancer of split 7

Transcription factor HES-7

BHLHB37; hHes7; bHLHb37  [Similar Products]

HES7_HUMAN

This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

HES7: Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation. Defects in HES7 are the cause of spondylocostal dysostosis type 4 (SCDO4). A rare condition of variable severity characterized by vertebral and costal anomalies. The main feature include dwarfism, vertebral fusion, hemivertebrae, posterior rib fusion, reduced rib number, and other rib malformations.

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: nucleus

Molecular Function: protein dimerization activity; DNA binding; transcription factor binding

Biological Process: somitogenesis; Notch signaling pathway; transcription, DNA-dependent; rhythmic process; mesoderm development; negative regulation of transcription from RNA polymerase II promoter; regulation of somitogenesis; skeletal development

Disease: Spondylocostal Dysostosis 4, Autosomal Recessive

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