Product Name
Corepressor interacting with RBPJ 1 (CIR1), Recombinant Protein
Full Product Name
Recombinant Human Corepressor interacting with RBPJ 1 (CIR1)
Product Gene Name
CIR1 recombinant protein
[Similar Products]
Product Synonym Gene Name
CIR1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-450aa, full length protein
Sequence
MGKSFANFMC KKDFHPASKS NIKKVWMAEQ KISYDKKKQE ELMQQYLKEQ ESYDNRLLMG DERVKNGLNF MYEAPPGAKK ENKEKEETEG ETEYKFEWQK GAPREKYAKD DMNIRDQPFG IQVRNVRCIK CHKWGHVNTD RECPLFGLSG INASSVPTDG SGPSMHPSEL IAEMRNSGFA LKRNVLGRNL TANDPSQEYV ASEGEEDPEV EFLKSLTTKQ KQKLLRKLDR LEKKKKKKDR KKKKFQKSRS KHKKHKSSSS SSSSSSSSSS TETSESSSES ESNNKEKKIQ RKKRKKNKCS GHNNSDSEEK DKSKKRKLHE ELSSSHHNRE KAKEKPRFLK HESSREDSKW SHSDSDKKSR THKHSPEKRG SERKEGSSRS HGREERSRRS RSRSPGSYKQ RETRKRAQRN PGEEQSRRND SRSHGTDLYR GEKMYREHPG GTHTKVTQRE
3D Structure
ModBase 3D Structure for Q86X95
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CIR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CIR1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004873.3
[Other Products]
NCBI GenBank Nucleotide #
NM_004882.3
[Other Products]
UniProt Primary Accession #
Q86X95
[Other Products]
UniProt Secondary Accession #
O95367; Q12804; Q4G1B9; Q6PJI4; Q8IWI2; A6NFI6; A8K8M4[Other Products]
UniProt Related Accession #
Q86X95[Other Products]
Molecular Weight
23,274 Da
NCBI Official Full Name
corepressor interacting with RBPJ 1
NCBI Official Synonym Full Names
corepressor interacting with RBPJ, 1
NCBI Official Symbol
CIR1 [Similar Products]
NCBI Official Synonym Symbols
CIR
[Similar Products]
NCBI Protein Information
corepressor interacting with RBPJ 1
UniProt Protein Name
Corepressor interacting with RBPJ 1
UniProt Synonym Protein Names
CBF1-interacting corepressor; Recepin
Protein Family
Corepressor interacting with RBPJ
UniProt Gene Name
CIR1 [Similar Products]
UniProt Synonym Gene Names
CIR [Similar Products]
UniProt Comments for CIR1
May modulate splice site selection during alternative splicing of pre-mRNAs (). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
Research Articles on CIR1
1. identified as a PAP-1 binding protein and as a splicing factor
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
