Full Product Name
GPSM2 Rabbit Polyclonal
Product Gene Name
anti-GPSM2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
G-protein signaling modulator 2 (AGS3-like, C. elegans)
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-GPSM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GPSM2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for GPSM2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_037428.3
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NCBI GenBank Nucleotide #
NM_013296.4
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UniProt Secondary Accession #
Q5T1N8; Q6IBL7; Q8N0Z5[Other Products]
UniProt Related Accession #
P81274[Other Products]
Molecular Weight
76,662 Da
NCBI Official Full Name
G-protein-signaling modulator 2
NCBI Official Synonym Full Names
G-protein signaling modulator 2
NCBI Official Symbol
GPSM2 [Similar Products]
NCBI Official Synonym Symbols
LGN; CMCS; PINS; DFNB82
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NCBI Protein Information
G-protein-signaling modulator 2
UniProt Protein Name
G-protein-signaling modulator 2
UniProt Synonym Protein Names
Mosaic protein LGN
Protein Family
G-protein-signaling modulator
UniProt Gene Name
GPSM2 [Similar Products]
UniProt Synonym Gene Names
LGN [Similar Products]
UniProt Entry Name
GPSM2_HUMAN
NCBI Summary for GPSM2
The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Comments for GPSM2
GPSM2: Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. Interacts with LLGL2. Interacts with INSC/inscuteable and probably with F2RL2. Ubiquitously expressed. Belongs to the GPSM family.
Protein type: G protein regulator, misc.
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: apical part of cell; cell cortex; cytoplasm
Molecular Function: G-protein alpha-subunit binding; GDP-dissociation inhibitor activity; identical protein binding; nucleotide binding; protein binding
Biological Process: establishment of mitotic spindle orientation; G-protein coupled receptor protein signaling pathway; maintenance of centrosome localization; mitotic spindle organization and biogenesis; regulation of catalytic activity
Disease: Chudley-mccullough Syndrome
Research Articles on GPSM2
1. results fit a model whereby LGN influences interphase microtubule dynamics in endothelial cells to regulate migration, cell adhesion, and sprout extension, and reveal a novel non-mitotic role for LGN in sprouting angiogenesis
Precautions
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Disclaimer
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