GPSM2, Blocking Peptide

G-protein-signaling modulator 2; Mosaic protein LGN; GPSM2; LGN

For Research Use Only. Not for use in diagnostic procedures.

The synthetic peptide sequence is selected from aa 133-143 of HUMAN GPSM2

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Small volumes of GPSM2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.

76,662 Da

G-protein signaling modulator 2

G-protein-signaling modulator 2

G-protein-signaling modulator 2

LGN  [Similar Products]

GPSM2_HUMAN

The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GPSM2: Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. Interacts with LLGL2. Interacts with INSC/inscuteable and probably with F2RL2. Ubiquitously expressed. Belongs to the GPSM family.

Protein type: G protein regulator, misc.

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: cell cortex; cytoplasm

Molecular Function: GDP-dissociation inhibitor activity; identical protein binding; protein binding

Biological Process: G-protein coupled receptor protein signaling pathway; maintenance of centrosome localization; mitotic spindle organization and biogenesis

Disease: Chudley-mccullough Syndrome

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