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TUBB2B, Monoclonal Antibody

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产品名称: TUBB2B, Monoclonal Antibody
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简单介绍

TUBB2B, Monoclonal Antibody


TUBB2B, Monoclonal Antibody  的详细介绍
Product Name

TUBB2B, Monoclonal Antibody

Full Product Name

Mouse Monoclonal [clone AT5B3] (Ig2a,k) to Human TUBB2B

Product Synonym Names
Anti-TUBB2B Antibody (clone AT5B3) IHC-plus; TUBB2B; BA506K6.1; Class IIb beta-tubulin; PMGYSA; RP11-506K6.1; Tubulin; beta 2B; Class II beta-tubulin isotype; Tubulin beta-2B chain; Tubulin; beta 2B class IIb; Human TUBB2B
Product Gene Name

anti-TUBB2B antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
phenotype 612850
3D Structure
ModBase 3D Structure for Q9BVA1
Clonality
Monoclonal
Isotype
Ig2a,k
Clone Number
AT5B3
Host
Mouse
Species Reactivity
Human
Purity/Purification
Protein G Purified
Form/Format
Phosphate buffered saline, pH 7.4, 0.1% sodium azide
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Recombinant human TUBB2b (aa1-445) purified from E Coli
Immunogen Type
Recombinant protein
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Other Notes
Small volumes of anti-TUBB2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Applications Tested/Suitable for anti-TUBB2B antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-TUBB2B antibody
IHC-P (5 ug/ml)

Immunohistochemistry (IHC) of anti-TUBB2B antibody
Anti-TUBB2B antibody IHC of human colon, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-TUBB2B antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-TUBB2B antibody
Anti-TUBB2B antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-TUBB2B antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TUBB2B. It may not necessarily be applicable to this product.
NCBI GI #
29788768
NCBI GeneID
347733
NCBI Accession #
NP_821080.1 [Other Products]
NCBI GenBank Nucleotide #
NM_178012.4 [Other Products]
UniProt Primary Accession #
Q9BVA1 [Other Products]
UniProt Secondary Accession #
A8K068[Other Products]
UniProt Related Accession #
Q9BVA1[Other Products]
Molecular Weight
49,953 Da
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NCBI Official Full Name
tubulin beta-2B chain
NCBI Official Synonym Full Names
tubulin, beta 2B class IIb
NCBI Official Symbol
TUBB2B  [Similar Products]
NCBI Official Synonym Symbols
PMGYSA; bA506K6.1
  [Similar Products]
NCBI Protein Information
tubulin beta-2B chain; class IIb beta-tubulin; class II beta-tubulin isotype; tubulin, beta polypeptide paralog
UniProt Protein Name
Tubulin beta-2B chain
Protein Family
Tubulin
UniProt Gene Name
TUBB2B  [Similar Products]
UniProt Entry Name
TBB2B_HUMAN
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NCBI Summary for TUBB2B
The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]
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UniProt Comments for TUBB2B
TUBB2B: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB2B is implicated in neuronal migration. Defects in TUBB2B are a cause of polymicrogyria asymmetric (PMGA). PMGA is a malformation of the cortex in which the brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination. Belongs to the tubulin family.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: microtubule; cytoplasm; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton

Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; neuron migration; transmembrane transport; microtubule-based process

Disease: Polymicrogyria, Symmetric Or Asymmetric
Research Articles on TUBB2B
1. The present study confirms that mutations in tubulin genes are responsible for complex brain malformation.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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