ShK – Stichodactyla toxin
Selective blocker of Kv1.3
如果您对该产品感兴趣的话,可以
产品名称: ShK – Stichodactyla toxin
Selective blocker of Kv1.3
产品型号:
产品展商: 其他品牌
产品文档: 无相关文档
简单介绍
ShK – Stichodactyla toxin
Selective blocker of Kv1.3
的详细介绍
ShK – Stichodactyla toxin
Selective blocker of Kv1.3
ShK (Stichodactyla helianthus Neurotoxin) has been isolated from the venom of the Carribean sea anemone Stoichactis helianthus. ShK inhibits voltage-dependent potassium channels. It blocks Kv1.3 (KCNA3) potently and also Kv1.1 (KCNA1), Kv1.4 (KCNA4) and Kv1.6 (KCNA6) respectively with a Kd of 11 pM, 16 pM, 312 pM and 165 pM. Interestingly, it was also demonstrated that ShK potently inhibits the hKv3.2b channel with an IC50 value of approximately 0.6 nM.